PHARMACOKINETICS AND BIOAVAILABILITY OF THIAMPHENICOL GLYCINATE HCL IN MALE GOATS

Bogzil, A. H.; Tohamy, M. A.

doi:10.21608/kvmj.2015.108730

PHARMACOKINETICS AND BIOAVAILABILITY OF THIAMPHENICOL GLYCINATE HCL IN MALE GOATS

Document Type : Original Article

Authors

A. H. Bogzil ¹
M. A. Tohamy ²

¹ Department of Pharmacology, toxicology and forensic medicine, Faculty of Veterinary Medicine, Omar Al Mukhtar University

² Pharmacology Department, Faculty of Veterinary Medicine, Beni-suef University, Egypt

10.21608/kvmj.2015.108730

Abstract

The Pharmacokinetic profile of thiamphenicol glycinate HCl was
studied in male goats following single intravenous and intramuscular
administration of 30 mg kg-1 b.wt. Thiamphenicol concentration in
serum was determined by microbiological assay using Bacillus
subtilis (ATCC 6633) as test organism. After intravenous injection the
serum thiamphenicol concentration time course was found to obey
two-compartment open model with distribution (t0.5(α)) and
elimination (t0.5(β)) half lives of 0.0.06 ± 0.003 and 1.20 + 0.163 h.,
respectively. Total body clearance (ClB) and steady state volume of
distribution (Vdss) were 1.025 ± 0.04 L kg-1 h-1 and 0.51± 0.010 L kg-1.,
respectively. After intramuscular administration the observed mean
peak serum concentration (Cmax) was 6.89 ± 0.052 μg ml-1 achieved
after maximum time (tmax) of 1.53 ± 0.08 hour post-injection.The
systemic bioavailability after intramuscular was 87.61 % . The plasma
protein binding percent was 13.3%.

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