PHARMACOLOGICAL STUDY ON THE EFFECT OF DICLAZURIL AND SEMDURAMICIN ON THE IMMUNE RESPONSE IN BRIOLERS

Document Type : Original Article

Authors

Animal Health Research Institute, provisional lab Kafer El-Sheikh Pharmacology

Abstract

The aim of the present workwas to study the effect of two anticoccidial drugs namely diclazuril and semduramicin on the immune response of briolers. Birds were divided into three equal groups, each of 50 chicks. The 1st .group received semduramicin (25 ppm). The 2nd group received diclazuril (1ppm) and 3rd group received only basal ration (control). All groups were vaccinated against Newcastle virus at 18 days and  were challenged with a  virulent strain of ND at the 21th day of age. Blood samples were collected from birds of each group at 25 days of the experiment. Five chickens of each group were slaughtered at the same age then the lymphoid organs (thymus, bursa and spleen) were carefully separated &weighed and each organ relative weight was determined.Number of dead birds were recorded daily till the end of the experiment (at 45 day). It was observed that administration of diclazuril and semduramicin in recommended doses has no significant changes on blood cell count. Moreover, the obtained results indicated that both drugs had no significant effects on createnine and uric acid serum levels and on the activities of  AST and ALT,. On the other hand, semduramicin induced a significant  decrease in the phagocytic activity, serum globulin  and HI titer. Additionally, semduramicin decreased the relative weights of bursa.

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Kafrelsheikh Veterinary Medical Journal
Volume 11, Issue 2
October 2013
Pages 55-68

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