The purpose of this study was to determine the pharmacokinetics and possible interactions of ciprofloxacin and diclofenac in healthy rabbits following intravenous injection. Six male adult chinchilla rabbits were used for the study. In a cross-over design (3 × 2) was used in two phases separated by a wash period (3 weeks), Ciprofloxacin was injected at a dose of 30 mg kg-1. They were given intravenously while diclofenac sodium at recommended dose at level of 1 mg kg -1, i.m. to each healthy rabbit. The concentration–time data were analyzed by two-compartmental (after i.v. dose). Plasma concentrations of ciprofloxacin were determined by HPLC. After a washout period, after the drugs were co-administered. The kinetic parameters of ciprofloxacin were significantly changed by administration of diclofenac. Based on these kinetic data, ciprofloxacin is likely to be effective in rabbits even in combination with diclofenac and suggested for treating infections caused by drug-sensitive pathogens in rabbits.
Shaheen, H., & El-Sheikh, M. (2011). PHARMACOKINETICS OF CIPROFLOXACIN AND ITS INTERACTION WITH DICLOFENAC AFTER INTRAVENOUS INJECTION IN HEALTHY RABBITS. Kafrelsheikh Veterinary Medical Journal, 9(1), 189-209. doi: 10.21608/kvmj.2011.113534
MLA
H.M. Shaheen; M.W. El-Sheikh. "PHARMACOKINETICS OF CIPROFLOXACIN AND ITS INTERACTION WITH DICLOFENAC AFTER INTRAVENOUS INJECTION IN HEALTHY RABBITS". Kafrelsheikh Veterinary Medical Journal, 9, 1, 2011, 189-209. doi: 10.21608/kvmj.2011.113534
HARVARD
Shaheen, H., El-Sheikh, M. (2011). 'PHARMACOKINETICS OF CIPROFLOXACIN AND ITS INTERACTION WITH DICLOFENAC AFTER INTRAVENOUS INJECTION IN HEALTHY RABBITS', Kafrelsheikh Veterinary Medical Journal, 9(1), pp. 189-209. doi: 10.21608/kvmj.2011.113534
VANCOUVER
Shaheen, H., El-Sheikh, M. PHARMACOKINETICS OF CIPROFLOXACIN AND ITS INTERACTION WITH DICLOFENAC AFTER INTRAVENOUS INJECTION IN HEALTHY RABBITS. Kafrelsheikh Veterinary Medical Journal, 2011; 9(1): 189-209. doi: 10.21608/kvmj.2011.113534
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