ORAL VACCINATION OF PUPPIES WITH THE CORE VACCINES (CANINE DISTEMPER; CANINE PARVO; CANINE HEPATITIS AND RABIES VACCINES)

Ali, Naglaa, I.; Salama, Zeinab, T.S.; El-Emam, Hemmat, S.

doi:10.21608/kvmj.2011.113541

ORAL VACCINATION OF PUPPIES WITH THE CORE VACCINES (CANINE DISTEMPER; CANINE PARVO; CANINE HEPATITIS AND RABIES VACCINES)

Document Type : Original Article

Authors

Veterinary Serum and Vaccine Research Institute Abassia-Cairo, P.O.B.131

10.21608/kvmj.2011.113541

Abstract

Four cell culture vaccines were prepared as single vaccines against canine distemper (CD); Canine parvo (CP); canine hepatitis (CH) and rabies. The first three vaccines were prepared as attenuated vaccines on Vero cells while rabies vaccine was prepared in BHK-21 cells as attenuated and inactivated vaccine. Such vaccines were used to vaccinate puppies' parentrally through the subcutaneous route and another time in the form of fish cake baits. In addition tetra dog vaccine was prepared from these vaccines and tested in puppies through the subcutaneous and oral routes. All of the prepared vaccine forms were found to be safe inducing no abnormal clinical signs post vaccination. Vaccinated puppies exhibiting good levels of specific CD; CP; CH and rabies antibodies, as measured by serum neutralization test. Such antibodies were capable to protect vaccinated puppies against challenge virulent with virus strains indicating that the oral delivery bait vaccines can protect dogs against the common contagious viral diseases and help to keep these infectious diseases under control.

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