Document Type : Original Article
Authors
1
Department of Pharmacology, and Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt
2
Department of Biochemistry , and Feed Deficiency Diseases, Animal Health Research Institute, Dokki, Cairo, Egypt
3
Department of Public Health and Zoonotic Diseases, Directorate of Veterinary Medicine, Kafr El- Sheikh, Egypt
Abstract
A total number of 160 apparently healthy male catfish (Clarias lazera)
weighed 95-105 gm, and with total length of 21-25 cm were exposed
to deltamethrin (DM) concentrations of 0.5 ug/L, for one week, and
0.02, and 0.01 ug/L for 4 weeks. Serum and internal organs (liver, and
kidney) samples were obtained for the determination of both liver and
kidney functions. Liver function tests revealed a non-significant
difference in serum total bilirubin, serum total globulins (S.G.),
serum albumin/globulin (A/G) ratio, serum triglycerides (TG) level,
serum alanine aminotransferase activity (S.ALT), serum alkaline
phosphatase activity (S.ALP), and a significant increase in serum
albumin (S.A.), serum total protein (S.T.P.), serum aspartate
aminotransferase (S.AST), and lactate dehydrogenase (S.LDH)
activities, and a significant decrease in serum total cholesterol and
serum total lipids (TL) level, by the exposure to the concentration 0.5
ug/L of DM for one week. There was also a significant increase in
serum total bilirubin, S. AST, S. ALT, S.ALP, and serum LDH
activities and a significant decrease in S.A. level, S.T.P. , serum A/G ratio, and a non-significant difference in S.G. content, by both
concentrations 0.01, and 0.02 ug/L of DM. The concentration 0.01
ug/L of DM only significantly increased serum cholesterol, TG, and
TL levels, while, the concentration 0.02 ug/L significantly decreased
the serum cholesterol, TG, and TL levels. Liver tissue showed excess
of melano-machrophage centers (MMCs), congestion, odema and
lymphocytic infiltrations after acute exposure to the concentration 0.5
ug/L of DM for one week, while After chronic exposure there were
congestion, hepatocytic degeneration and necrosis which were
accompanied with excess of MMCs. Kidney function test revealed a
significant increase in serum urea, serum creatinine (S.Cr.) and serum
uric acid level by the concentration 0.5 ug/L for one week, and 0.02
ug/L for 4 weeks, and only and a significant increase in both urea and
uric acid levels by the concentration 0.01 ug/L for 4 weeks. The renal
tubules were damaged with congestion of the various glomerular as
well as intertubular blood vessels in addition to several areas of
hemorrhages and lymphocytic infiltration after acute exposures, while
the posterior kidneys suffered damage of the glomeruli with several
tubular degenerations and necrosis in addition to an excess of
mononuclear cell reactions after the chronic exposure to the high
concentration 0.02 ug/L of DM.
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