ANTICOCCIDIAL EFFICACY OF METRONIDAZOLE

Aziz, M.A.; Abd El-Wahab, T.M.; El-Shazly, K.M.; Saif, A.S.

doi:10.21608/kvmj.2009.107185

ANTICOCCIDIAL EFFICACY OF METRONIDAZOLE

Document Type : Original Article

Authors

¹ Department of Pharmacology, Faculty of Veterinary Medicine, Kaferelseikh University

² Department Parasitology, Animal Health Research Institute, Kafrelsheikh Branch

³ Department of Pharmacology, Animal Health Research Institute, Kaferelsheikh Branch

10.21608/kvmj.2009.107185

Abstract

This study was carried out to study the efficacy of metronidazole as
anticoccidial drug at two levels of doses (25 and 50 mg / kg B.W) for 5
consecutive days via drinking water. one hundred and fifty mixed sex
one day old Arbor Acres F.s. chicks were divided into six equal main
groups. All were fed on ordinary ration free from any anticoccidial
agents allover the experiment (41 days). -The first group was non
infected non treated (negative control). the second group was treated
without infection with 25 mg / kg of metronidazole (flagyl susp Alex
co) ,the third group was treated with 50 mg/kg B.W of metronidazole
without infection The fourth group was infected non treated group < br />(positive control) .The fifth and sixth groups were infected with E.
tenella (50.000 oocysts / bird) at 18 days of age and treated with( 25
and 50mg /kg B.W) of metronidazole respectively after symptoms
appeared for 5 consecutive days .
The evaluation was based on clinical signs, lesion scores, oocyst counts,
and histopathological findings of treated and infected non treated
group. The results showed that the infected non treated group (positive
control) showed the typical signs of coccidiosis including depression,
loss of appetite and bloody droppings one week post infection. Variable
degrees of illness were recorded until the end of experiment.
Medication of metronidazole after infection at both dose levels improved
the clinical signs, oocyst counts and Lesion score,The mortality rate
as well as the epithelial lining of the intestinal gland of infected treated
group than that of the infected non treated group, in addition to the
degeneration of most of the developmental stages of E tenella in treated
Groups.

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