SOME PHARMACOLOGICAL STUDIES ON DRUG INTERACTIONS

Abd El Azi, Magdy; El Shazly, Kamal; El Zoghby, Aml F.; Amer, Dina, E.M

doi:10.21608/kvmj.2015.109847

SOME PHARMACOLOGICAL STUDIES ON DRUG INTERACTIONS

Document Type : Original Article

Authors

¹ Pharmacology Department, Faculty of Veterinary Medicine Kafrelsheikh Universit

² Pharmacology Department, Faculty of Veterinary Medicine Kafrelsheikh University

³ Animal Health Research Institute- Tanta

10.21608/kvmj.2015.109847

Abstract

In recent years great extensions were achieved in poultry industry in Egypt to increase its production, this trend is unfortunately hampered by recurrent episodes of diseases like coccidiosis ana E. coli infection, worldwide bacterial infections affecting all ages of birds, are of continuing economic concern to poultry production due to major losses includes high morbidity and mortality rates, loss of body weight and other bird’s performance. Control of both coccidiosis and colibacillosis is very important in poultry farms, which depend mainly on the use of certain anticoccidial drug as diclazuril and antimicrobials as fosfomycin.
This study was directed to test the interaction between fosfomycin and diclazuril in case of infection of E.coli.
In the present work one hundred and twenty, one-day old mixed sex avain 48 broiler chicks were used from a commercial hatchery. Chicks were divided into 8 equal groups each of 15 chicks. All groups were taken same treat and were fed on ordinary ration free from any drugs all over the experiment (42 days).
Chickens were infected with pathogenic field strains of E. coli (strain O78) through intratracheal route in dose 0.2 ml.
The groups were treated with fosfomycin in drinking water after the clinical signs had appeared 3^rd day post of E.coli infection for 5 successive days from 28^th day to 32^nd day old age using recommended therapeutic dose 160 mg / kg B.wt. daily in drinking water or feed for 3-5 days , the groups were treated with (diclazuril) in drinking water for 3 successive days from 30^th day to 32^nd days old age used in the recommended therapeutic dose from the producer 1 ml Diclosol liquid /4 liters of drinking water (2.5 ppm). The results showed improvement in infected chickens condition represented in disappearing of clinical signs and decreasing mortality rate and using fosfomycin and diclazuril together did not effect on general activity of chickens.

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