EFFECT OF GARLIC AND ATORVASTATIN ON LEPTIN AND LIPID PROFILE IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS

Taha, Nabil M.; Abdel-Hamid, Hatem S.; Sadek, Kadry M.; Abdalaziz, Ahmed Z.

doi:10.21608/kvmj.2014.110154

EFFECT OF GARLIC AND ATORVASTATIN ON LEPTIN AND LIPID PROFILE IN TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS

Document Type : Original Article

Authors

¹ Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Egypt.

² Department of poultry diseases, Faculty of Veterinary Medicine, Damanhur University, Egypt.

³ Department of Biochemistry, Faculty of Veterinary Medicine, Damanhur University, Egypt.

10.21608/kvmj.2014.110154

Abstract

Hyperlipidemia is widely known to be the major risk factor for the development of cardiovascular diseases. This study was conducted to determine the effect of Garlic on Leptin hormone and Lipid Profile in Triton x-100 induced hyperlipidemic rats compared with standard hypolipidemic Atorvastatin. A total number of 60 albino rats were allocated into six equal groups, 10 rats each. The first group was kept on Standard pellet diet (served as normal control), the second group was kept on 1% garlic added to standard pellet diet, the third group was administered with standard Atorvastatin 10 mg/kg p.o. daily (served as standard), the forth group was given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. (served as Triton control), fifth and sixth groups were given a single dose of triton at a dose 100 mg/kg and repeated every two weeks, i.p. and the fifth group was given garlic 1% added to standard pellet diet while sixth group was administered with standard Atorvastatin 10 mg/kg p.o. (served as treated groups), after inducing hyperlipidemia (for 6 weeks). Results showed that, garlic significantly decreased cholesterol, LDL-C, VLDL-C and TG and significantly increased HDL compared with triton x-100 -treated group. On the other hand, there were a non significant differences in total lipid, phospholipids and leptin levels compared with triton x-100 -treated group. We concluded that, Garlic has definite antihyperlipidemic activity in Triton X-100 induced hyperlipidemia model which is equipotent activity when compared with Atorvastatin. This might returned in addition to its own hypolipidemc activity to increased leptin sensitivity in hypothalamus. Further studies on Garlic needed to identify the possible mechanism of action on leptin hormone.

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