INFLUENCE OF TOPICAL BROWN ALGAE (CYSTOSEIRA MYRICA) EXTRACT APPLICATION ON WOUND HEALING IN RATS

Document Type : Original Article

Authors

1 Departments of Surgery, Anaesthesiology and Radiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

2 Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt.

3 Marine Science Department, Faculty of Science, Port Said University, Egypt.

Abstract

Objectives:To investigate the feasibility and safety of brown algae (Cystoseira myrica) extract in the improvement of wound healing process.
Materials and Method:Full thickness excision wounds (1.5 x 1.5 cm) were created under general anesthesia on the back of the rats. These rats were divided into two groups; control group (Group C) and brown algae extract topical application group (Group B). Each wound area was measured on days 0, 3, 6, 9, 12, 15 and 18 post-wounding. On day 18 post-wounding, animals were sacrificed.  Quantification of granulation tissue and their biochemical and histological aspects in control as well as treated groups were estimated.
Results: Brown algae extract showed significant increase in wound contraction and formation of scars on days 9, 12, 15 and18 post wounding (p < 0.001). Histologically, extracellular matrix deposition and epithelialization were promoted in Group B.
Conclusion: The present results suggest that brown algae (Cystoseira myrica) extract can effectively improve wound healing in a full-thickness skin wound model. Use of brown algae (Cystoseira myrica) extract might therefore facilitate development and improvement of wound healing treatments in future.

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