COMPARATIVE STUDY ON DIFFERENT METHODS OF EXPERIMENTAL ARTHRITIS INDUCTION IN EQUINE

Document Type : Original Article

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Faculty of Veterinary Medicine, Kafrelsheikh University

Abstract

Animal models for osteoarthritis (OA) are essential for studying the disease process and evaluating different therapeutic protocols. To date, no ideal OA animal model has been described. This study is a trial to find an equine osteoarthritic model that mimics the naturally occurring one in the horse. The study utilized 15 donkeys, divided into 3 equal groups (n=5). The radio carpal joint of the right forelimb of donkeys were injected with 25mg monoiodoacetate (group A), 50mg allogenous cartilage particles (group B), or normal saline (group C) over a period of 70 days. Lameness score, carpal circumference, joint flexion angel, Synovial fluid analysis (total protein and WBC count), were measured weekly over 70 days. There were marked significant change in the clinical signs and synovial fluid analysis between group A and B compared to group C. ACP and MIA in the donkey are suitable models to be investigated as a viable and less expensive alternative for an equine OA model. Injection of ACP may be a good model to study the disease process of osteoarthritis as well as evaluation of diseases modifying osteoarthritis drugs. However, injection on MIA is useful to study the pain effect and acute stage of arthritis as well as evaluation of Non-steroidal anti-inflammatory drugs.

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Kafrelsheikh Veterinary Medical Journal
Volume 11, Issue 1
April 2013
Pages 113-132

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