STUDIES ON THEILERIOSIS IN CROSSBRED CALVES BEFORE AND AFTER TREATMENT BY BUPARVA-QUONE UNDER THE EFFECT OF LOCAL CONDITIONS IN UPPER EGYPT

Document Type : Original Article

Authors

1 Animal Health Research Institute, Port Said Regional Laboratory.

2 Animal Health Research Institute, Port Said Regional Laboratory

Abstract

Thisstudyaimed toestimatethe drastic effects of Theileria annulata infectiononthegeneral health condition and some haematological and biochemical parameters and to evaluate the efficacy of Buparvaquone in treatment of crossbred calves.Bup-arvaquonewas injected atadose rate of 2.5 mg/kg BW as a single dose (group A) or double doses with 48 h intervals(group B).The rate of Parasitaemia in the infectedcalves reached12-28 %.Pyre-xia reached 40.5-41.3 °C.Anaemia was a hall-mark of the disease accompanied by reduction of the mean values of blood serum total protein, albumin, globulin, glucose, cholesterol, calcium, and phosphorous while non significant changes in the conce-ntrations of blood serum triglycerides and magnesium were recorded if compared to the non infected control calves (group C). Animals in group A showed elevated rectal temperature (40-40.6 °C) for 5-8 days and the rate of parasitaemia declined slowly till it reached its minimal level (4.5 %) 20 deys post treatment (PT). Also, 2 calves were died at the day7and8PT with high rate of parasitaemia(33-41%)and pyrexia (41.6°C). In group B, the temperature subsided 1-2 days after the 2nd dose and the rate of parasitaemia reached to less than 1% at the day 12.Haematological parameters remained reduced PT in group < /em>A,while theyrestoredtheirnormalvaluesexcept total leucocytic count in group B. Biochemical parameters were restored except serum globulin conc-entrationingroup < /em>B,whihremaindingroup < /em>A.From theseinvestigations we can concluded that buparvaquone at a dose rate 2.5 mg/kg BW in double dose with 48 h intervals is more efficient than a single dose under the local environment of Upper Egypt.

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