The pharmacokinetic properties of difloxacin were investigated follo-wing intravenous, intramuscular and oral administration of 10 mg/kg body weight, in non-infected and experimentally mycoplasma infected chickens. Serum concentrations of difloxacin were assayed microbial-ogically after intravenous, intramuscular and oral administrations. difl-oxacin residues were detected in chicken tissues following repeated oral administrations in non-infected and infected chickens. Following a single intravenous injection, the serum difloxacin level was best approximated to follow a two-compartment open model. The elimination half-life (t0.5b) was 4.58 + 0.008 h. The volume of distri-bution at steady-state (Vdss) was 2.12 + 0.07 L/kg and the mean resid-ence time (MRT) was 3.91 + 0.07 h. Following a single oral administration of 10 mg/kg b.wt difloxacin,the recorded results revealed that serum level of difloxacin was higher in infected chickens than non infected chickens. Serum concentrations peaked one hour post-drug administration with half lifes of absorption (t0.5ab) of 0.48 + 0.02 and 0.37 + 0.02 hour in non infected and myc-oplasma infected chickens, respectively. The extent of serum protein binding of difloxacin in non-infected chickens was 15.44 + 1.24%. Systemic bioavailability after oral and intramuscular administration of difloxacininnon-infectedchickenswas75.87and 93.03%,respectively. Following oral and intramuscular administration of 10 mg difloxacin / kg b.wt once daily for 5 consecutive days in infected and non infected chic-kens, the drug could be detected in all tested tissue up to 48 hours after last oral and intramuscular dose in non infected and infected chickens.
Abdel Aziz, M., El Shazly, K., & El-Gazar, W. (2005). DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM. Kafrelsheikh Veterinary Medical Journal, 3(1), 97-113. doi: 10.21608/kvmj.2005.112448
MLA
M.I. Abdel Aziz; K.A. El Shazly; W.M. El-Gazar. "DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM". Kafrelsheikh Veterinary Medical Journal, 3, 1, 2005, 97-113. doi: 10.21608/kvmj.2005.112448
HARVARD
Abdel Aziz, M., El Shazly, K., El-Gazar, W. (2005). 'DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM', Kafrelsheikh Veterinary Medical Journal, 3(1), pp. 97-113. doi: 10.21608/kvmj.2005.112448
VANCOUVER
Abdel Aziz, M., El Shazly, K., El-Gazar, W. DISPOSITION KINETICS OF DIFLOXACIN IN NORMAL AND EXPERIMENTALLY INFECTED CHICKENS WITH MYCOPLASMA GALLISEPTICUM. Kafrelsheikh Veterinary Medical Journal, 2005; 3(1): 97-113. doi: 10.21608/kvmj.2005.112448
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