The pharmacokinetic profile of danofloxacin, a fluoroquinolone antibacterial was studied in one, two-months and one year old Egyptian buffalo calves following a single intravenous and intramuscular administration of 1.25 mg kg-1 b.wt. in a cross over study with 15-day wash out period. Drug concentrations in serum were determined by microbiological assay technique. After i.v administration the serum concentration-time curve of danofloxacin was best fitted using two-compartment open model. The drug was rapidly distributed as indicated by short distribution half-lives (t½(α)) of 0.093, 0.117 and 0.194 h in one , two-months and one year old calves, respectively. The elimination half-life was relatively longer in one- and two-months than in one year old calves (t½(β)) 5.802 compared to 4.941 and 3.795 h., respectively. The volumes of distribution at steady-state (Vdss) 1.259, 1.347 and 1.490 L kg-1), total body clearance (ClB)= 0.155, 0.195 and 0.280 L kg-1 h-1) and mean residence time (MRT = 8.127, 6.886 and 5.334 h) were recorded in the three ages, respectively. Ara under the plasma concentration vs. time curve(AUC) was decreased with age 8.564, 6.651 and 4.615 ug ml-1 h-1 in the three ages, respectively). Following intramuscular administration, the absorption half-life (t½(ab)) was 0.421, 0.462 and 0.425 h in the three ages, respectively. The maximum serum concentrations (Cmax) of 0.541, 0.434 and 0.363 ug ml-1 were attained after (tmax) 1.853, 1.810 and 1.712 h in the three ages, respectively. The elimination half-life (t½(el)) and MRT values of danofloxacin were longer in one-month old calves compared to two months and one year old calves. The systemic intramuscular bioavailabilities were 96.672, 98.136 and 94.366 %, while the in-vitro serum protein-binding tendencies were 6.678, 9.176 and 13.572 %, for one, two- months old and one year old calves, respectively.
El-Gendy, A., & Tohamy, M. (2007). EFFECT OF AGE ON PHARMACOKINETICS OF DANOFLOXACIN IN EGYPTIAN BUFFALO CALVES. Kafrelsheikh Veterinary Medical Journal, 5(1), 16-31. doi: 10.21608/kvmj.2007.115847
MLA
A.A.M. El-Gendy; M.A. Tohamy. "EFFECT OF AGE ON PHARMACOKINETICS OF DANOFLOXACIN IN EGYPTIAN BUFFALO CALVES", Kafrelsheikh Veterinary Medical Journal, 5, 1, 2007, 16-31. doi: 10.21608/kvmj.2007.115847
HARVARD
El-Gendy, A., Tohamy, M. (2007). 'EFFECT OF AGE ON PHARMACOKINETICS OF DANOFLOXACIN IN EGYPTIAN BUFFALO CALVES', Kafrelsheikh Veterinary Medical Journal, 5(1), pp. 16-31. doi: 10.21608/kvmj.2007.115847
VANCOUVER
El-Gendy, A., Tohamy, M. EFFECT OF AGE ON PHARMACOKINETICS OF DANOFLOXACIN IN EGYPTIAN BUFFALO CALVES. Kafrelsheikh Veterinary Medical Journal, 2007; 5(1): 16-31. doi: 10.21608/kvmj.2007.115847
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